Development of Bacterial Resistance to Anti-Microbial Botanicals
With the significant increase in antibiotic resistance bacteria, antibiotic use has become challenging. Many botanicals have well-characterized antibacterial activity and our researchers are investigating the rate at which bacteria can develop resistance to many of these botanicals.
Characterization of the mechanism of action associated with antibacterial botanicals
Characterization of botanicals effective against Staphylococcus and MRSA
A Comparison of the Anti-Staphylococcus aureus Activity of Extracts from Commonly Used Medicinal Plants
In order to answer today's call for effective treatments against Staphylococcus aureus, S. aureus, we evaluated and compared various botanical extracts that have historically been suggested as useful for their antimicrobial properties against S. aureus.
Results: The antimicrobial activity observed for the botanical extracts used in this comparative evaluation of efficacy included both bacteriostatic and bacteriocidal activity against S. aureus. Highly effective botanicals including Salvia officinalis, Eucalyptus globulus, Coleus forskohlii, Coptis chinensis, Turnera diffusa, and Larrea tridentata exhibited MIC values ranging from 60 to 300 μg/mL and a 106-fold reduction in bacterial replication. Arctostaphylos uva-ursi and Allium sativum were slightly less effective, exhibiting MIC values ranging from 90 to 400 μg/mL and a 105-fold reduction, while Anemopsis californica gave MIC value of 360 μg/mL and a 104-fold reduction in bacterial replication. Many botanicals, especially at lower doses, had an initial inhibitory effect followed by a recovery in bacterial replication. Such botanicals included E. globulus, C. chinensis, T. diffusa, A. californica, and Berberis vulgaris.
Conclusions: Our data demonstrate that S. officinalis, E. globulus, C. forskohlii, A. uva-ursi, C. chinensis, T. diffusa, A. californica, A. sativum, and L. tridentata all show promising direct antimicrobial activity against S. aureus. For many of these botanicals, strong bacteriocidal activity was observed at higher concentrations, but even at lower concentrations, bacteriostatic activity was evident. Other botanicals including B. vulgaris, Baptisia tinctoria, and Glycyrrhiza glabra showed moderate activity against S. aureus, while Schisandra chinensis, Echinacea angustifolia, and Polygonum multiflorum were shown to be ineffective.
Read the full article published in The Journal of Alternative and Complementary Medicine here.
Characterization of botanicals against the plague
Identification of botanicals with biofilm inhibition activity