Nelson EO, Kozin AF, Ruiz G, Lasku A, Langland JO. Treatment of athlete’s plantar warts using a botanical blend: a case report. Altern Ther Health Med. 2017 Feb 27;
Arndt WD, White SD, Johnson BP, Huynh T, Liao J, Harrington H, et al. Monkeypox virus induces the synthesis of less dsRNA than vaccinia virus, and is more resistant to the anti-poxvirus drug, IBT, than vaccinia virus. Virology. 2016 Oct;497:125–35.
Wolf J, Deng Y, Langland J. Treatment of medically refractory chronic daily vomiting with acupuncture and Chinese herbal medicine: a case report. Journal of Chinese Medicine. 2016 Jun;111:31–6.
Ferreira V., Ruiz G., Jacobs BL., Denzler K., Waters R., Chamberlain R., Proefrock KJ., Langland JO. Treatment of Verruca vulgaris (common warts) with a synergistic botanical blend. NDNR. 2016 May;
Denzler KL, Huynh TP, Jacobs BL, Langland JO. Melissa officinalis extract inhibits herpes simplex virus-I glycoprotein B interaction with heparin sulfate. Herbal Medicine:  Open Access. 2016 Apr;
Ferreira V., Dickerson W., Farr D., Barraza M., Banker R., Dutton J., Cervigni M., Willhauck M., Tifre L., Mayman S., Stone S., Bushman S., Hull G., Morgan R., Hoover T., Mittman A., Sparks L., Smithers J., Miles D., Calvert D., Langland J. The Effect of botanical tinctures and essential oils on the growth and morphogenesis of Candida albicans. Herbal Medicine:  Open Access. 2016 Mar;
Ruiz GG, Nelson EO, Kozin AF, Turner TC, Waters RF, Langland JO. A Lack of bioactive predictability for marker compounds commonly used for herbal medicine standardization. PLoS ONE. 2016;11(7):e0159857.
Denzler K, Moore J, Harrington H, Morrill K, Huynh T, Jacobs B, et al. Characterization of the physiological response following in vivo administration of Astragalus membranaceus. Evidence-Based Complementary and Alternative Medicine. 2016;2016:1–13.
Allen, J., Deng, Y., and Langland, J.O. Treatment of chronic migraine pain with acupuncture and herbal medication. Journal of Chinese Medicine. 2016;110:18–22.
Wolf J, Sparks L, Deng Y, Langland J. Restoration of function With acupuncture following severe traumatic brain injury: a case report. Glob Adv Health Med. 2015 Nov;4(6):52–7.
Grise DE, McAllister HM, Langland J. Improved clinical outcomes of patients with type 2 diabetes mellitus utilizing integrative medicine: a case report. Glob Adv Health Med. 2015 May;4(3):57–61.
Virdee K, Musset J, Baral M, Cronin C, Langland J. Food-specific IgG Antibody-guided Elimination Diets Followed by Resolution of Asthma Symptoms and Reduction in Pharmacological Interventions in Two Patients: A Case Report. Glob Adv Health Med. 2015 Jan;4(1):62–6.
Wheeler M., Oskin J., Langland J. Alternating Symptoms in the Homoeopathic Treatment of Bipolar Disorder. Platinum Metallicum: A Case Report. American Journal of Homeopathic Medicine. 2015 Winter;108(4):145–53.
Ferreira, V., Jacobs, B.L., Denzler, K., Waters, R., Chamberlain, R., Proefrock, K.J., and Langland, J.O., Jacobs BL, Waters RF, Chamberlain R., Proefrock K.J., Langland JO. Treatment of Herpes Zoster with botanical interventions: case report. NDNR. 2015;
Swanson M, Langland JO. Voices of naturopathic research. NDNR. 2014 Aug;
Snowden R, Harrington H, Morrill K, Jeane L, Garrity J, Orian M, et al. A comparison of the anti-Staphylococcus aureus activity of extracts from commonly used medicinal plants. J Altern Complement Med. 2014 May;20(5):375–82.
Morrill K, May K, Leek D, Langland N, Jeane LD, Ventura J, et al. Spectrum of antimicrobial activity associated with ionic colloidal silver. J Altern Complement Med. 2013 Mar;19(3):224–31.
Arneson, D., Black, S., Waters, R., Langland, J.O., and Gelinas, B. Liquid CMO vs. Fibromyalgia: an open clinical pilot study using a liquid emulsion form of cetyl myristoleate. NDNR. 2012 Jul;
Arndt W, Mitnik C, Denzler KL, White S, Waters R, Jacobs BL, et al. In Vitro Characterization of a nineteenth-century therapy for smallpox. Vermund SH, editor. PLoS ONE. 2012 Mar 9;7(3):e32610.
Langland JO, Langland EV. Fauna of a 400-million-year-old coral reef in Arizona. Rocks & Minerals. 2012 Jan 31;87(1):40–4.
Ameson D, Black S, Gelinas B, Langland J, Waters R, Black S., Gelinas B., Langland J., Waters R. Novel fibromyalgia therapy:  Open pilot study using a liquid emulsion form of cetyl myrisoleate. NDNR. 2012;8:1–6.
White SD, Conwell K, Langland JO, Jacobs BL. Use of a negative selectable marker for rapid selection of recombinant vaccinia virus. BioTechniques. 2011 May;50(5):303–9.
Willis KL, Langland JO, Shisler JL. Viral double-stranded RNAs from vaccinia virus early or intermediate gene transcripts possess PKR activating function, resulting in NF-kappaB activation, when the K1 protein is absent or mutated. J Biol Chem. 2011 Mar 11;286(10):7765–78.
Denzler KL, Waters R, Jacobs BL, Rochon Y, Langland JO. Regulation of inflammatory gene expression in PBMCs by immunostimulatory botanicals. PLoS ONE. 2010 Sep 3;5(9):e12561.
Jacobs BL, Langland JO, Kibler KV, Denzler KL, White SD, Holechek SA, et al. Vaccinia virus vaccines: past, present and future. Antiviral Res. 2009 Oct;84(1):1–13.
Zhang P, Langland JO, Jacobs BL, Samuel CE. Protein kinase PKR-dependent activation of mitogen-activated protein kinases occurs through mitochondrial adapter IPS-1 and is antagonized by vaccinia virus E3L. J Virol. 2009 Jun;83(11):5718–25.
Jentarra GM, Heck MC, Youn JW, Kibler K, Langland JO, Baskin CR, et al. Vaccinia viruses with mutations in the E3L gene as potential replication-competent, attenuated vaccines: scarification vaccination. Vaccine. 2008 Jun 2;26(23):2860–72.
Ye Y, Hauns K, Langland JO, Jacobs BL, Hogue BG. Mouse hepatitis coronavirus A59 nucleocapsid protein is a type I interferon antagonist. J Virol. 2007 Mar;81(6):2554–63.
Langland JO, Kash JC, Carter V, Thomas MJ, Katze MG, Jacobs BL. Suppression of proinflammatory signal transduction and gene expression by the dual nucleic acid binding domains of the vaccinia virus E3L proteins. J Virol. 2006 Oct;80(20):10083–95.
Langland JO, Cameron JM, Heck MC, Jancovich JK, Jacobs BL. Inhibition of PKR by RNA and DNA viruses. Virus Res. 2006 Jul;119(1):100–10.
Torrence PF, editor. Viral Countermeasures to the Host Interferon Response: Role of the Vaccinia Virus E3L and K3L Genes. In: Antiviral drug discovery for emerging diseases and bioterrorism threats. Hoboken, N.J: Wiley-Interscience; 2005. p. 353–78.
Langland JO, Jacobs BL. Inhibition of PKR by vaccinia virus: role of the N- and C-terminal domains of E3L. Virology. 2004 Jul 1;324(2):419–29.
Vijaysri S, Talasela L, Mercer AA, Mcinnes CJ, Jacobs BL, Langland JO. The Orf virus E3L homologue is able to complement deletion of the vaccinia virus E3L gene in vitro but not in vivo. Virology. 2003 Sep 15;314(1):305–14.
Langland JO, Kao P, Jacobs BL. Regulation of IL-2 gene expression and nuclear factor-90 translocation in vaccinia virus-infected cells. J Interferon Cytokine Res. 2003 Sep;23(9):489–500.
Langland JO, Jacobs BL. The role of the PKR-inhibitory genes, E3L and K3L, in determining vaccinia virus host range. Virology. 2002 Jul 20;299(1):133–41.
He Y, Tan SL, Tareen SU, Vijaysri S, Langland JO, Jacobs BL, et al. Regulation of mRNA translation and cellular signaling by hepatitis C virus nonstructural protein NS5A. J Virol. 2001 Jun;75(11):5090–8.
Langland JO, Kao PN, Jacobs BL. Nuclear factor-90 of activated T-cells: A double-stranded RNA-binding protein and substrate for the double-stranded RNA-dependent protein kinase, PKR. Biochemistry. 1999 May 11;38(19):6361–8.
Jacobs BL, Langland JO, Brandt T. Characterization of viral double-stranded RNA-binding proteins. Methods. 1998 Jul;15(3):225–32.
Langland J, Langland L, Roth D. Differential localization and accumulation of the plant double stranded RNA-dependent protein kinase during virus infection. Plant Physiology and Biochemistry. 1998 May;36(5):395–400.
Rager KJ, Langland JO, Jacobs BL, Proud D, Marsh DG, Imani F. Activation of antiviral protein kinase leads to immunoglobulin E class switching in human B cells. J Virol. 1998 Feb;72(2):1171–6.
Jacobs BL, Langland JO. Reovirus Sigma3 Protein: dsRNA-Binding and Inhibition of PKR. Current Topics in Microbiology and Immunology. 1998;185–96.
Langland JO, Langland L, Zeman C, Saha D, Roth DA. Developmental regulation of a plant encoded inhibitor of eukaryotic initiation factor 2 alpha phosphorylation. Plant J. 1997 Aug;12(2):393–400.
Kibler KV, Shors T, Perkins KB, Zeman CC, Banaszak MP, Biesterfeldt J, et al. Double-stranded RNA is a trigger for apoptosis in vaccinia virus-infected cells. J Virol. 1997 Mar;71(3):1992–2003.
Karupiah G, editor. Viral inhibitors of interferon action: inhibitors of the PKR and 2’5’ oligoadenylate synthetase/RNase L pathways. In: Gamma Interferon in Antiviral Defense. New York Berlin Heidelberg London Paris Tokyo Hong Kong Barcelona Budapest: Springer; 1997. (Medical intelligence unit).
Jacobs BL, Langland JO. When two strands are better than one: the mediators and modulators of the cellular responses to double-stranded RNA. Virology. 1996 May 15;219(2):339–49.
Langland JO, Langland LA, Browning KS, Roth DA. Phosphorylation of plant eukaryotic initiation factor-2 by the plant-encoded double-stranded RNA-dependent protein kinase, pPKR, and inhibition of protein synthesis in vitro. J Biol Chem. 1996 Feb 23;271(8):4539–44.
Roth, D. A. Landgland J.O. Functional significance of plant encoded dsRNA dependent protein activity in the regulation of protein synthesis. Current Top in Plant Biochem  Mol  Biol. 1996;15:77–8.
Langland, J.0., Langland, L.A. and Roth, D.A. Polyanion regulation of the plant-encoded dsRNA-dependent protein kinase, pPKR. Plant Phys and Biochem. 1996;34:521–6.
Langland JO, Jin S, Jacobs BL, Roth DA. Identification of a plant-encoded analog of PKR, the mammalian double-stranded RNA-dependent protein kinase. Plant Physiol. 1995 Jul;108(3):1259–67.
Langland JO, Pettiford SM, Jacobs BL. Nucleic acid affinity chromatography: preparation and characterization of double-stranded RNA agarose. Protein Expr Purif. 1995 Feb;6(1):25–32.
Langland JO, Pettiford S, Jiang B, Jacobs BL. Products of the porcine group C rotavirus NSP3 gene bind specifically to double-stranded RNA and inhibit activation of the interferon-induced protein kinase PKR. J Virol. 1994 Jun;68(6):3821–9.
Park H, Davies MV, Langland JO, Chang HW, Nam YS, Tartaglia J, Paoletti E, Jacobs BL, Kaufman RJ, Venkatesan S. TAR RNA-binding protein is an inhibitor of the interferon-induced protein kinase PKR. PNAS. 1994;91(11):4713–7.
Park, H., Davies, M.V., Langland, J.0., Chang, H.W., Nam, Y.S., Tartaglia, J., Paoletti, E., Jacobs, B.L. Kaufman, R.J. and Venkatesan, S. A Cellular protein that binds several structured viral RNAs is an inhibitor of the interferon-induced PKR protein kinase in vitro and in vivo. Proceedings of the National Academy of Sciences. 1994;91:4713–7.
Langland JO, Jacobs BL. Cytosolic double-stranded RNA-dependent protein kinase is likely a dimer of partially phosphorylated Mr = 66,000 subunits. J Biol Chem. 1992 May 25;267(15):10729–36.

Langland JO. A method for inserting genetic material into genomic DNA. M10–168L.
Langland JO. Carnivorous botanical extracts with antiviral, anticarcinogenic, analgesic and antipruritic properties for the treatment of disease. M13–037L.
Langland JO. Cell death and oncolytic vaccinia virus mutants. D16-060.
Langland JO. Extract of the botanical Melissa officinalis with antiviral activity against ebola virus. M15–180L.
Langland JO. Method and compositions for use of carnivorous plant extracts in the treatment of poxvirus infections. M9–087L.
Langland JO. Mutants of vaccinia virus as oncolytic agents. M3–091L, 2003.
Langland JO. Mutated poxviruses which affect dsRNA-binding as vaccine and gene therapy vectors. 6,750,043 and 6,942,955, 2005.
Langland JO. Poxviruses containing novel genes for PKR inhibitors in place of E3L as vaccine and gene therapy vectors. M1-026, 2000.
Langland JO. Resistance to viruses and viroids in transgenic plants and animals expressing dsRNA-binding protein. 5,990,388, 1999.